Phytosphingosine

Phytosphingosine is a sphingoid base — the backbone molecule from which the skin builds ceramides AP and NP. Applied topically at 0.2–0.5%, it supplies raw material for natural ceramide synthesis while itself exhibiting antimicrobial and anti-inflammatory activity, including action against acne bacteria. Clinical research found phytosphingosine enhances acne treatment outcomes when combined with benzoyl peroxide. It also regulates differentiation of keratinocytes, supporting orderly barrier renewal. Found in many sensitive-skin and blemish lines for exactly this dual benefit: barrier repair plus blemish control. Evening use pairs well with ceramide creams to complete the lipid renewal cycle.